NuLink Alkyne

Alkyne Reagent, SKU NCPD01, Water Soluble


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Product Description

Safety and Documentation




The copper-catalyzed azide-alkyne cycloaddition (CuAAC) has been widely utilized in applications of bioconjugation. The CuAAC reaction involves the coupling of an azide and a terminal alkyne to form a stable triazole linkage between two disparate molecular entities. While this coupling processes is straight forward neither azides nor alkynes occur naturally in biomolecules. NuChemie’s PDMIA reagent is the simplest easy-to-use method for the incorporation and quantification of a terminal alkyne into almost any biomolecule platform.


Product Highlights


  • Rapid – Alkyne incorporation can be complete in less than 15 min with clean product ready in under 1 hr.
  • Quantifiable – Alkyne incorporation is quantified by a simple single-point U.V. scan (335 nm).
  • "Click" Monitoring – By using PDMIA with one of NuChemie's quantifiable azides, UV monitoring can be used to track reaction progress of the azide-alkyne cycloaddition.
  • Dual Monitoring – NuLink PDMIA renders labeled molecules with unique absorbance (335 nm) and fluorescent (420 nm) signatures
  • Minimal byproducts – NuLink regents produce only inert CO2 upon reaction. Unreacted or hydrolyzed reagent is easily removed by means of a number of downstream processing steps.
  • Water Soluble – Highly water soluble (> 20 mg/ml)




Chemical Formula: C15H17BrN2O3, Molecular Weight: 352.04

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Safety Information

No Safety Information is available for this product at this time. This product is made available for research purposes only.

Lot Analysis



Protocols for the labeling of proteins, including antibodies (ABs) and carrier proteins have been provided in the documents below. Each document details reaction conditions, and includes information regarding buffer compatibility, reaction kinetics, and troubleshooting for the most commonly encountered problems.